Professor Gillian M. Griffiths
I am a cell biologist and immunologist who has focused on understanding the fundamental cell biological mechanisms that drive cytotoxic T cell killing. I find scientific research endlessly fascinating and have always been intrigued by the parallels between seemingly disparate biological systems such as the immune synapse and primary cilia.
Beyond the lab, I enjoy bird watching and cycling in remote parts of Scotland.
Anna Lippert, PhD
I'm Anna, a Sir Henry Wellcome Trust fellow working on the role of forces during T cell activation and killing. During my 4 years I will work between three groups to combine 3D lightsheet imaging with intracellular force sensors and patient-derived T cells with various actin deficiencies.
Apart from sciencing, I spend my time with ballroom dancing and petting other people's cats.
I'm Philippa, a final year PhD student. I carried out a high throughput screening of single gene knockout lines produced at the Wellcome Trust Sanger Institute to identify genes involved in CTL effector function as part of the 3i consortium. I'm now investigating some of the hits.
Arianne Richard, PhD
I am an MRC Skills Development Postdoctoral Fellow jointly sponsored by the Griffiths and Marioni labs. I'm interested in how T cells change their gene expression in response to stimulation. In particular I use single-cell measurement techniques to look at how molecular events are coordinated within individual cells.
Claire Ma, MD
Claire is a Wellcome Trust Clinical PhD student who is also a respiratory registrar. She just submitted her eLife paper and returned to clinic to help with the current pandemic. We look forward to her return to lab!
I am a first year PhD student on the Wellcome Trust II&I programme. I am investigating the role of forces in CTL activation and killing by implementing a range of force probes in CTLs. These probes will be combined with CRISPR gene editing to elucidate which genes are involved in the T cell's ability to sense force and activate thereafter. This is of particular interest since cancer cells have been shown to exhibit decreased stiffness and thereby evade the immune system.
Carla Vázquez Amos
I am the lab supervisor and research assistant. I organise the lab and our mouse colonies. I am also the all-important gold star awarder!
Currently I am working on an antibody generation project, supporting the lab's various research aims.