Professor Gillian M. Griffiths

FMedSci, FRS

I am a cell biologist and immunologist who has focused on understanding the fundamental cell biological mechanisms that drive cytotoxic T cell killing.  I find scientific research endlessly fascinating and have always been intrigued by the parallels between seemingly disparate biological systems such as the immune synapse and primary cilia.

 

Beyond the lab, I enjoy bird watching and cycling in remote parts of Scotland.

Jane Stinchcombe, PhD

I use electron microscopy to investigate the cell biology of the CTL at the ultrastructural level. In particular, I am interested in the ultrastructural changes that take place during target engagement and understanding why they are important during killing.

Yukako Asano, PhD

I'm interested in mechanisms of cell polarity used in T cells. I use live cell imaging to look at this and have generated many of the movies on the website.

Anna Lippert, PhD

I'm Anna, a Sir Henry Wellcome Trust fellow working on the role of forces during T cell activation and killing. During my 4 years I will work between three groups to combine 3D lightsheet imaging with intracellular force sensors and patient-derived T cells with various actin deficiencies.

Apart from sciencing, I spend my time with ballroom dancing and petting other people's cats.

Philippa Barton

I'm Philippa, a final year PhD student. I carried out a high throughput screening of single gene knockout lines produced at the Wellcome Trust Sanger Institute to identify genes involved in CTL effector function as part of the 3i consortium. I'm now investigating some of the hits.

Tiphaine Douanne, PhD

I'm a post-doc who joined the lab recently and will be using a combination of microscopy and biochemistry to study the morphological and molecular similarities between the immune synapse and the primary cilia.

Miriam Lisci

I am a PhD student and my project has focused on understanding the role of mitochondria in effector CD8+ T cells using imaging and molecular biology approaches in mouse and human primary CD8+ T cells.   

Arianne Richard, PhD

I am an MRC Skills Development Postdoctoral Fellow jointly sponsored by the Griffiths and Marioni labs. I'm interested in how T cells change their gene expression in response to stimulation. In particular I use single-cell measurement techniques to look at how molecular events are coordinated within individual cells.

Claire Ma, MD

Claire is a Wellcome Trust Clinical PhD student who is also a respiratory registrar.  She just submitted her eLife paper and returned to clinic to help with the current pandemic.  We look forward to her return to lab!

Adam Rochussen

I am a first year PhD student on the Wellcome Trust II&I programme. I am investigating the role of forces in CTL activation and killing by implementing a range of force probes in CTLs. These probes will be combined with CRISPR gene editing to elucidate which genes are involved in the T cell's ability to sense force and activate thereafter. This is of particular interest since cancer cells have been shown to exhibit decreased stiffness and thereby evade the immune system.

Carla Vázquez Amos

I am the lab supervisor and research assistant. I organise the lab and our mouse colonies. I am also the all-important gold star awarder!

 

Currently I am working on an antibody generation project, supporting the lab's various research aims.