Key papers:
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Stinchcombe JC, Asano Y, Kaufman CJG, Bӧhlig K, Peddie CJ, Collinson LM, Nadler A, Griffiths GM. Ectocytosis renders T cell receptor signaling self-limiting at the synapse. Science, 380(6647):818-823, doi: 10.1126/science.abp8933, (2023).
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Barton PR, Davenport AJ, Hukelmann J, Cantrell DA, Stinchcombe JC and Griffiths GM. Super-killer CTLs are generated by single gene deletion of Bach2. European Journal of Immunology, Epub ahead of print. doi: 10.1002/eji.202249797 (2022).
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Lisci M, Griffiths GM. Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity. Trends in Cellular Biology, Epub ahead of print. doi: 10.1016/j.tcb.2022.05.007 (2022).
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Richard AC, Frazer G, Ma CY, Griffiths GM. Staggered starts in the race to T cell activation. Trends in Immunology, 42(11):994-1008. doi: 10.1016/j.it.2021.09.004 (2021)
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Lisci M, Barton PR, Randzavola LR, Ma CY, Marchingo JM, Cantrell DA, Paupe V, Prudent J, Stinchcombe JC and Griffiths GM. Mitochondrial translation is required for sustained killing by cytotoxic T cells. Science, 15;374(6565):eabe9977. doi: 10.1126/science.abe9977 (2021).
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Frazer G, Gawden-Bone CM, Dieckmann NMG, Asano Y and Griffiths GM. Signal strength controls the rate of polarization within CTLs during killing. Journal of Cell Biology, 220 (10): e202104093 (2021).
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Douanne T, Stinchcombe JC and Griffiths, GM. Teasing out function from morphology: Similarities between primary cilia and immune synapses. Journal of Cell Biology 20 (6): e202102089. doi: 10.1083/jcb.202102089 (2021).
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Douanne, T and Griffiths, GM. Cytoskeletal control of the secretory immune synapse. Current Opinion in Cell Biology, 71, pp.87-94 (2021).
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Ma C, Marioni J, Griffiths GM and Richard A. Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling. eLife, 9:e53948. doi: 10.7554/eLife.53948 (2020).
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Randzavola LO, Strege K, Juzans M, Asano Y, Stinchcombe JC, Gawden-Bone CM, Seaman MNJ, Kuijpers T. and Griffiths GM. Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity. Journal of Clinical Investigation, 129(12), pp.5600-5614 (2019).
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Ritter AT, Kapnick SM, Murugesan S, Schwartzberg PL, Griffiths GM, Lippincott-Schwartz J. Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes. Proc. Natl Acad. Sci. USA 114(32):E6585-E6594. doi: 10.1073/pnas.1710751114 (2017).
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Stinchcombe JC, Randzavola L, Angus KL, Mantell JM, Verkade P & Griffiths GM. Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis. Current Biol. 25, 3239–3244 (2015).
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Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NM, Chen BC, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW, Betzig E, Lippincott-Schwartz J, Griffiths GM. Actin depletion initiates events leading to granule secretion at the immunological synapse. Immunity 42, 864-876. doi: 10.1016/j.immuni.2015.04.013 (2015).
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Jenkins, M. R. et al. Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. eLife 3:e01310 (2014).
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de la Roche, M. et al. Hedgehog signaling controls T-cell killing at the immunological synapse. Science 342, 1247–1250 (2013).