Key papers:

CTL activate as they recognise their targets

  • Ma, C, Marioni, J, Griffiths, GM and Richard, A. Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling. eLife, 9:e53948. doi: 10.7554/eLife.53948 (2020).

  • Randzavola LO, Strege K, Juzans M, Asano Y, Stinchcombe JC, Gawden-Bone CM, Seaman MNJ, Kuijpers T. and Griffiths GM. Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity. Journal of Clinical Investigation, 129(12), pp.5600-5614 (2019).

  • Ritter AT, Kapnick SM, Murugesan S, Schwartzberg PL, Griffiths GM, Lippincott-Schwartz J. Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes. Proc. Natl Acad. Sci. USA 114(32):E6585-E6594. doi: 10.1073/pnas.1710751114 (2017).

  • Stinchcombe JC, Randzavola L, Angus KL, Mantell JM, Verkade P & Griffiths GM. Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis. Current Biol. 25, 3239–3244 (2015).

  • Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NM, Chen BC, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW, Betzig E, Lippincott-Schwartz J, Griffiths GM. Actin depletion initiates events leading to granule secretion at the immunological synapse. Immunity 42, 864-876. doi: 10.1016/j.immuni.2015.04.013 (2015).

  • Jenkins, M. R. et al. Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. eLife 3:e01310 (2014).

  • de la Roche, M. et al. Hedgehog signaling controls T-cell killing at the immunological synapse. Science 342, 1247–1250 (2013).